METHODS FOR CONTROLLING T CELL PROLIFERATION

摘要

The technology relates generally to the field of immunology and relates in part to compositions and methods for controlling the proliferation of T cells, for example, therapeutic T cells. The methods further relate to compositions and methods for inducing an immune response in a subject.

主权项

1. A composition, comprising a nucleic acid that comprises a polynucleotide encoding an inducible chimeric signaling molecule, wherein the inducible chimeric signaling molecule comprises a membrane targeting region, a multimerizing region and a co-stimulatory polypeptide cytoplasmic signaling region selected from the group consisting of CD27, CD28, ICOS, 4-1BB, CD40, RANK/TRANCE-R, and OX40.