发明名称 |
IL-33 ANTAGONISTS AND USES THEREOF |
摘要 |
The present invention provides interleukin-33 (IL-33) antagonists comprising one or more IL-33-binding domains and one or more multimerizing domains and methods of using the same. According to certain embodiments of the invention, the IL-33-binding domains can comprise anIL-33-binding portion of an ST2 protein and/or an extracellular portion of an I L-1 RAcP protein. The IL-33 antagonists of the invention are useful for the treatment of diseases and disorders associated with IL-33 signaling and/or IL-33 cellular expression, such as infectious diseases, inflammatory diseases, allergic diseases and fibrotic diseases. |
申请公布号 |
WO2014152195(A1) |
申请公布日期 |
2014.09.25 |
申请号 |
WO2014US27058 |
申请日期 |
2014.03.14 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MURPHY, ANDREW, J.;PAPADOPOULOS, NICHOLAS, J.;ORENGO, JAMIE |
分类号 |
A61K38/17;C07K14/715 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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