| 发明名称 |
INHIBITION OF LEUKOTRIENE SYNTHESIS AND ACTIVITY IN THE TREATMENT OF SONIC HEDGEHOG-ASSOCIATED MEDULLOBLASTOMA |
| 摘要 |
Treating Sonic Hedgehog-Associated Medulloblastoma comprises inhibiting the synthesis or biologic activity of leukotrienes that drive Nestin expression in cancerous or precancerous granule neuron precursors and that further drive growth and proliferation of medulloblastoma cells through Nestin-mediated aberrant Sonic Hedgehog signaling. |
| 申请公布号 |
WO2014151451(A1) |
申请公布日期 |
2014.09.25 |
| 申请号 |
WO2014US25756 |
申请日期 |
2014.03.13 |
| 申请人 |
INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER;YANG, ZENG-JIE |
发明人 |
YANG, ZENG-JIE |
| 分类号 |
A61K31/00;A61K31/381;A61K31/404;A61K31/405;A61K31/47;A61P35/00 |
主分类号 |
A61K31/00 |
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