A transgenic mouse is provided comprising in its genome an endogenous » light chain immunoglobulin locus comprising a deletion of the endogenous mouse V»1-J»3-C»3-J»1-C»1 gene cluster and a deletion of a region spanning from V»2 to J»2 of the endogenous mouse V»2-V»3-J»2-C»2-J»4-C»4 gene cluster. Mouse cells and mouse embryos are also provided.
申请公布号
ZA201300062(B)
申请公布日期
2014.09.25
申请号
ZA20130000062
申请日期
2013.01.03
申请人
REGENERON PHARMACEUTICALS INC
发明人
MACDONALD LYNN;STEVENS SEAN;GURER CAGAN;MURPHY ANDREW J;HOSIAWA KAROLINA A
