Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia

摘要

Methods useful in the diagnosis, prognosis, treatment and management of acute myeloid leukemia are disclosed. One method entails predicting survival of a patient with acute myeloid leukemia, said method comprising: analyzing a genetic sample isolated from the patient for the presence of cytogenetic abnormalities and a mutation in at least one of FLT3, NPMI, DNMT3A, NRAS, CEBPA, TET2, WTI, IDHI, IDH2, KIT, RUNXI, MLL-PTD, ASXLI, PHF6, KRAS, PTEN, P53, HRAS, and EZH2.