摘要 |
The present invention relates to pharmaceutical compositions containing a solid dispersion of N- [2,4-B is( 1, 1 -dimethy lethyl)-5 -hydroxypheny 1] - 1,4-dihydro-4-oxoquinoline-3 - carboxamide including formulations of the solid dispersions into powders, granules and mini- tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition. |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
DOKOU, ELENI;JAMZAD, SHAHLA;CAESAR JR., JOHN P.;FAWAZ, MAJED;DAS, LAURA;GU, CHONG-HUI;HURTER, PATRICIA NELL;ISRANI, MEGHNA JAI;JOHNSTON, MEGHAN M.;KNEZIC, DRAGUTIN;KUZMISSION, ANDREW G.;WANG, HONGREN |