| 发明名称 |
CHARACTERIZATION OF CHO-MIF GENE AND PROTEIN, AND USE THEREOF |
| 摘要 |
The present invention is concerned with the specific and highly sensitive detection of specific CHO-MIF (macrophage migration inhibitory factor from Chinese Ovarian Hamster cell line) complexes in the production of anti-MIF antibodies. The present invention is further concerned with the provision of specific antibodies which can be used for a CHO-MIF detection method. The present invention is also concerned with a CHO MIF knockout cell line and use thereof. The present invention also provides preparations obtained from recombinant production in CHO cell lines which are essentially free of CHO-MIF. |
| 申请公布号 |
US2014287443(A1) |
申请公布日期 |
2014.09.25 |
| 申请号 |
US201214350187 |
申请日期 |
2012.10.04 |
| 申请人 |
Baxter Healthcare SA ;Baxter International Inc. |
发明人 |
Kerschbaumer Randolf J.;Voelkel Dirk;Antoine Gerhard;Scheiflinger Friedrich;Mudde Geert C. |
| 分类号 |
G01N33/68;C07K16/24 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the detection of CHO-MIF contaminations in a monoclonal anti-MIF antibody preparation, comprising the step of
contacting the anti-MIF antibody preparation with a polyclonal anti-CHO-MIF antibody, affinity purified against CHO-MIF. |
| 地址 |
Glattpark (Opfikon) CH |
