NANOPARTICLE-BASED DELIVERY SYSTEM WITH OXIDIZED PHOSPHOLIPIDS AS TARGETING LIGANDS FOR THE PREVENTION, DIAGNOSIS AND TREATMENT OF ATHEROSCLEROSIS

摘要

Disclosed are nanoparticle-based medicine/nutrient delivery system that are coated or incorporated with oxidized phospholipids as targeting ligands. Such delivery systems can specifically target macrophages, which are determinant cells in the aortic wall for atherosclerotic lesion development, to significantly increase bioavailability and specificity for the prevention, diagnosis and treatment of atherosclerosis.

主权项

1. A composition, comprising:
a plurality of nanoparticles comprising one or more oxidized phospholipids encapsulated within, adhered to a surface of, or integrated into the structure of the nanoparticles, wherein the one or more oxidized phospholipids target to atherosclerotic lesion sites.