| 发明名称 |
Modified Gram-Negative Bacteria For Use As Vaccines |
| 摘要 |
The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host. |
| 申请公布号 |
US2014286996(A1) |
申请公布日期 |
2014.09.25 |
| 申请号 |
US201414296495 |
申请日期 |
2014.06.05 |
| 申请人 |
Institut National de la Sante et de la Recherche Medicale (INSERM) ;Centre National de la Recherche Scientifique - CNRS ;Universite de la Mediterranee - Aix-Marseille II ;Universidad de Navarra |
发明人 |
Gorvel Jean-Pierre;Arce Gorvel Vilma;Iriarte Maite;Moriyon Ignacio;Conde-Alvarez Raquel |
| 分类号 |
A61K39/39;A61K39/02 |
主分类号 |
A61K39/39 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the treatment of brucellosis, comprising the step of administering to a subject in need thereof a therapeutically effective amount of a gram-negative bacterium carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said gram-negative bacterium,
wherein said glycosyltransferase is selected from the group consisting of the glycosyltransferases having an amino acid sequence of SEQ ID NO:1 or SEQ ID NO: 21 and homologues thereof having an amino acid sequence having at least 50% of identity with SEQ ID NO: 1 or SEQ ID NO: 21, and wherein said inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacterium results in the synthesis of a LPS having a modified core. |
| 地址 |
Paris FR |
