发明名称 |
APELIN FUSION PROTEINS AND USES THEREOF |
摘要 |
The invention provides a fusion protein or polypeptide comprising an apelin peptide fused to a multimerizing component. The invention also provides a fusion protein or polypeptide comprising an apelin peptide fused to an Fc domain, a fragment of an Fc domain, or a variant of an Fc domain. Apelin Fc-fusion polypeptides are capable of binding to the apelin receptor (APLNR). Apelin Fc-fusion polypeptides are capable of activating the APLNR and have improved pharmacokinetic properties compared to apelin peptides that are not fused to an Fc or an Fc fragment. Apelin Fc-fusion polypeptides are useful in diseases and conditions related to cardiovascular function, diabetes, cancer, obesity and other apelin-related conditions. |
申请公布号 |
WO2014152955(A1) |
申请公布日期 |
2014.09.25 |
申请号 |
WO2014US28384 |
申请日期 |
2014.03.14 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
STEVIS, PANAYIOTIS;GROMADA, JESPER;MURPHY, ANDREW |
分类号 |
C07K14/47;A61K38/10;A61K38/17;C07K7/08 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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