MEASUREMENT OF CELLULAR FMRP LEVELS FOR HIGH THROUGHPUT DRUG SCREENING AND DIAGNOSIS OF FRAGILE X SYNDROME

摘要

Kits and methods for the measurement of the FMR1 gene product, FMRP, are disclosed. The present kits include highly selective fluorophore-labeled antibodies that enable Förster (Fluorescence) resonance energy transfer (FRET) assays for the quantification of FMRP, which can in turn be used in methods for treating patients with underlying CCG-repeat mutations and for screening therapeutic moieties.