发明名称 METHODS AND SYSTEMS FOR IDENTIFYING A PHYSIOLOGICAL STATE OF A TARGET CELL
摘要 <p>Embodiments of various aspects described herein are directed to methods, systems, and kits for identifying a functional or physiological state of a target cell. The inventions described herein are based on a novel approach that combines biochemical expression measurements of a sample (e.g., gene expression data) with mapping of the measurements onto a graphical representation of a plurality of reference points (loci). Each reference point corresponds to a reference sample with a known phenotype and reflects interrelationships between multi-dimensional biochemical expression measurements of the reference samples. By locating the sample relative to reference points on the graphical representation, the physiological or functional state of the sample can be identified. The methods, systems and kits described herein can be used for various applications, including, e.g., but not limited to, determining an effect of a perturbagen on a target cell, molecule screening, and diagnosis and/or treatment of a subject.</p>
申请公布号 WO2014152939(A1) 申请公布日期 2014.09.25
申请号 WO2014US28328 申请日期 2014.03.14
申请人 PRESIDENT AND FELLOWS OF HARVARD COLLEGE 发明人 KOHANE, ISAAC;PALMER, NATHAN
分类号 C40B30/00 主分类号 C40B30/00
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