发明名称 |
COMPOSITIONS AND METHODS FOR DENGUE VIRUS CHIMERIC CONSTRUCTS IN VACCINES |
摘要 |
Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells. |
申请公布号 |
WO2014150939(A2) |
申请公布日期 |
2014.09.25 |
申请号 |
WO2014US24603 |
申请日期 |
2014.03.12 |
申请人 |
TAKEDA VACCINES, INC;THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES |
发明人 |
STINCHCOMB, DAN, T.;HUANG, CLAIRE, Y.;KINNEY, RICHARD, M.;LIVENGOOD, JILL, A. |
分类号 |
A61K39/12 |
主分类号 |
A61K39/12 |
代理机构 |
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