发明名称 |
2-HYDROXYGLUTARATE AS A BIOMARKER FOR CHRONIC HYPOXIA |
摘要 |
The present invention provides biomarkers for sensitive, specific, accurate and quantitative diagnosis and assessment of chronic hypoxia. In particular, the present invention provides 2-hydroxyglutarate as a biomarker that is differentially produced in chronic hypoxia. Furthermore, embodiments of the invention are able to differentiate between chronic and acute hypoxia. Assays for levels of 2-hydroxyglutarate may be used alone or in conjunction with additional biomarkers of hypoxia to increase the precision of analysis. In particular embodiments of the invention, the level of 2-hydroxyglutarate and at least one second biomarker may be assayed to generate a hypoxic profile that can be compared to a reference or control profile, thereby diagnosing a subject as normoxic, chronically hypoxic, or acutely hypoxic. |
申请公布号 |
EP2780700(A1) |
申请公布日期 |
2014.09.24 |
申请号 |
EP20120850119 |
申请日期 |
2012.11.18 |
申请人 |
MEMORIAL SLOAN KETTERING CANCER CENTER |
发明人 |
WISE, DAVID, R.;WARD, PATRICK, S.;THOMPSON, CRAIG, B. |
分类号 |
G01N33/00;A61K31/522;A61K35/19;C12Q1/68;G01N33/53;G01N33/68 |
主分类号 |
G01N33/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|