PROCESS FOR PREPARING R-GOSSYPOL L-PHENYLALANINOL DIENAMINE

摘要

This invention relates to a process for preparing R-gossypol L-phenylalaninol dienamine using non-chromatographic purification methods. In particular, the invention is directed to resolution of R- and S-gossypol L-phenylalaninol dienamine by crystallization. R-gossypol L-phenylalaninol dienamine is a useful intermediate for the preparation of R-(−)-gossypol and R-(−)-gossypol acetic acid co-crystal. R-(−)-Gossypol acetic acid and its co-crystal is useful for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.