| 摘要 |
A method of evaluating a sample of thyroid tissue from a patient comprises the steps of assaying the expression level for two or more gene expression products in the sample to generate test data, correlating said test data with gene expression data obtained from at least 75 training samples of thyroid tissue; and, based on said correlating, identifying the sample of thyroid tissue as malignant, benign, non-cancerous, non-malignant, or normal. The correlation preferably comprises applying an algorithm that was trained with said gene expression data obtained from at least 75 training samples of thyroid tissue, with pathologies selected from normal thyroid, follicular adenoma, parathyroid, follicular carcinoma, lymphocytic thyroiditis, follicular variant papillary thyroid carcinoma, papillary thyroid carcinoma, nodular hyperplasia, medullary thyroid carcinoma, Hurthle cell carcinoma, Hurthle cell adenoma, anaplastic thyroid carcinoma, metastatic melanoma, metastatic renal carcinoma, metastatic breast carcinoma, or metastatic B cell lymphoma. |
