发明名称 |
SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES |
摘要 |
<p>The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.</p> |
申请公布号 |
PT1999259(E) |
申请公布日期 |
2014.09.24 |
申请号 |
PT20070752295T |
申请日期 |
2007.03.05 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
PIN WANG;INCHAN KWON;SOOJIN SON;YI TANG;DAVID A. TIRRELL |
分类号 |
C12N15/09 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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