Method of treating neuronal injury by administering magnesium chloride and PEG

摘要

The invention provides methods and kits for treatment of pain or inflammation. In one embodiment, the kit comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, an intra-articular administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.

主权项

1. A method of reducing the volume of lesion due to a spinal cord injury or a traumatic brain injury in a subject in need thereof, the method comprising:
a) delivering to the subject a first injectable composition comprising magnesium chloride and 20-30% weight/volume of polyethylene glycol (PEG) in saline, wherein said magnesium chloride and PEG act synergistically to treat the injury; b) providing the dose of Mg in said magnesium chloride to be within a range from 0.115 to 0.230 mmol of Mg/kg of the subject's weight and providing the dose for PEG to be within a range from 0.7 to 1.4 g of PEG/kg of the subject's weight for the first injectable composition; c) delivering to the subject a second injectable composition comprising magnesium chloride and 20-30% weight/volume of PEG in saline within 24 hours of delivering the first injectable composition wherein said magnesium chloride and PEG act synergistically to treat the injury; d) providing the dose of Mg in said magnesium chloride to be within a range from 0.115 to 0.230 mmol of Mg/kg of the subject's weight and the dose for PEG to be within a range from 0.7 to 1.4 g of PEG/kg of the subject's weight for the second injectable composition; and e) observing at least 29% improvement in lesion volume over a similar dosage of Mg administered alone in saline due to the synergistic effect of co-administering Mg and PEG.