| 发明名称 | Antibodies | ||
| 摘要 | The present invention relates to the use of VEGF antagonists and a novel anti-α5β1 antibody for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to compositions and kits comprising novel anti-α5β1 antibodies and methods of making and using them. | ||
| 申请公布号 | US8840887(B2) | 申请公布日期 | 2014.09.23 |
| 申请号 | US201113112839 | 申请日期 | 2011.05.20 |
| 申请人 | Genentech, Inc. | 发明人 | Liang Wei-Ching;Plowman Gregory D.;Wu Yan;Ye Weilan |
| 分类号 | A61K39/00;C07K16/28 | 主分类号 | A61K39/00 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A method for treating solid tumor in a subject comprising administering a VEGF antagonist and a humanized anti-α5β1 antibody, wherein the humanized anti-α5β1 antibody comprises a light chain variable domain having a sequence set forth in any one of SEQ ID NOS:1, 2, 3, or 4 and a heavy chain variable domain having a sequence set forth in any one of SEQ ID NOS:5, 6, 7, 8, or 9. | ||
| 地址 | South San Francisco CA US | ||