发明名称 Fungicidal N-(2-phenoxyethyl)carboxamide derivatives and their aza, thia and sila analogues
摘要 The present invention relates to fungicide N-(2-phenoxyethyl)carboxamide derivatives of formula (I), their aza, thia and sila analogs, their process of preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. Formula (1) wherein A, T, W, X, n and Z3 to Z7 represent various substituents.;
申请公布号 US8841332(B2) 申请公布日期 2014.09.23
申请号 US200913876381 申请日期 2009.07.30
申请人 Bayer Intellectual Property GmbH 发明人 Bennabi Samir;Benting Jurgen;Brunet Stephane;Desbordes Philippe;Dahmen Peter;Gary Stephanie;Grosjean-Cournoyer Marie-Claire;Rama Rachel;Rinolfi Philippe;Toquin Valerie;Voerste Arnd;Wachendorff-Neumann Ulrike
分类号 A61K31/415;A61K31/4164;A61K31/41;A61K31/425;A61K31/42;A61K31/40;A61K31/34;C07D285/06;C07D417/02;C07D277/20;C07D413/02;C07D231/02;C07D207/30;A01N43/08;A01N43/78;A01N43/36;A01N43/82;A01N43/56;A01N43/80;C07D231/20;C07D277/56;C07D261/18;C07D207/34;C07D307/68;C07D231/14 主分类号 A61K31/415
代理机构 Ostrolenk Faber LLP 代理人 Ostrolenk Faber LLP
主权项 1. A compound of formula (I)wherein A is a carbo-linked, unsaturated or partially saturated, 5-membered heterocyclyl group that can be substituted by up to four groups R; T is selected from the group consisting of O and S; W is selected from the group consisting of O, S, SO, SO2, N—Ra and SiZ1Z2; n is 0, 1, or 2, each X is selected from the group consisting of a halogen atom, a nitro, a cyano, an isonitrile, a hydroxy, an amino, a sulfanyl, a pentafluoro-λ6-sulfanyl, a formyl, a formyloxy, a formylamino, a carboxy, a carbamoyl, a N-hydroxycarbamoyl, a carbamate, a (hydroxyimino)-C1-C6-alkyl, a C1-C8-halogenoalkyl having 1 to 9 halogen atoms, a C1-C8-alkyl, a C2-C8-alkenyl, a C2-C8-halogenoalkenyl comprising up to 9 halogen atoms that can be the same or different, a C2-C8-alkynyl, a C2-C8-halogenoalkynyl comprising up to 9 halogen atoms that can be the same or different, a C1-C8-alkylamino, a di-C1-C8-alkylamino, a C1-C8-alkoxy, a C1-C8-halogenoalkoxy having 1 to 9 halogen atoms, a C1-C8-alkoxy-C1-C8-alkyl, a C1-C8-alkoxy-C1-C8-alkoxy, a C1-C8-alkylsulfanyl, a C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms, a C2-C8-alkenyloxy, a C2-C8-halogenoalkenyloxy having 1 to 9 halogen atoms, a C2-C8-alkynyloxy, a C2-C8-halogenoalkynyloxy having 1 to 9 halogen atoms, a C3-C8-cycloalkyl, a C3-C7-cycloalkyl-C2-C8-alkenyl, a C3-C7-cycloalkyl-C2-C8-alkynyl, a C3-C8-halogenocycloalkyl having 1 to 9 halogen atoms, a C3-C7-cycloalkyl-C3-C7-cycloalkyl, a C1-C8-alkyl-C3-C7-cycloalkyl, a C6-C14-bicycloalkyl, a C1-C8-alkylcarbonyl, a C1-C8-halogenoalkylcarbonyl having 1 to 9 halogen atoms, a C1-C8-alkylcarbamoyl, a di-C1-C8-alkylcarbamoyl, a N—C1-C8-alkyloxycarbamoyl, a C1-C8-alkoxycarbamoyl, a N—C1-C8-alkyl-C1-C8-alkoxycarbamoyl, a C1-C8-alkoxycarbonyl, a C1-C8-halogenoalkoxy carbonyl having 1 to 9 halogen atoms, a C1-C8-alkylcarbonyloxy, a C1-C8-halogenoalkylcarbonyloxy having 1 to 9 halogen atoms, a C1-C8-alkylcarbonylamino, a C1-C8-halogenoalkylcarbonylamino having 1 to 9 halogen atoms, a C1-C8-alkylaminocarbonyloxy, a di-C1-C8-alkylaminocarbonyloxy, a C1-C8-alkyloxycarbonyloxy, a C1-C8 alkylsulfenyl, a C1-C8-halogenoalkylsulfenyl having 1 to 9 halogen atoms, a C1-C8 alkylsulfinyl, a C1-C8-halogenoalkylsulfinyl having 1 to 9 halogen atoms, a C1-C8-alkylsulfonyl, a C1-C8-halogenoalkylsulfonyl having 1 to 9 halogen atoms, a C1-C8-alkoxyimino, a (C1-C8-alkoxyimino)-C1-C8-alkyl, a (C2-C8-alkenyloxyimino)-C1-C8-alkyl, a (C2-C8-alkynyloxyimino)-C1-C8-alkyl, a (benzyloxyimino)-C1-C8-alkyl, a tri(C1-C8-alkyl)silyl, a tri(C1-C8-alkyl)silyl-C1-C8-alkyl, a benzyloxy that can be substituted by up to 5 groups Q, a benzylsulfanyl that can be substituted by up to 5 groups Q, a benzylamino that can be substituted by up to 5 groups Q, an aryl that can be substituted by up to 5 groups Q, an aryloxy that can be substituted by up to 5 groups Q, an arylamino that can be substituted by up to 5 groups Q, an arylsulfanyl that can be substituted by up to 5 groups Q, an aryl-C1-C8-alkyl that can be substituted by up to 5 groups Q, an aryl-C2-C8-alkenyl that can be substituted by up to 5 groups Q, an aryl-C2-C8-alkynyl that can be substituted by up to 5 groups Q, an aryl-C3-C1-cycloalkyl that can be substituted by up to 5 groups Q, a pyridinyl that can be substituted by up to 4 groups Q and a pyridinyloxy that can be substituted by up to 4 groups Q; Z1 and Z2 are independently selected from the group consisting of a C1-C8-halogenoalkyl having 1 to 5 halogen atoms, a C1-C8-alkyl, a C2-C8-alkenyl, a C2-C8-alkynyl, a C3-C8-cycloalkyl, a C3-C8-halogenocycloalkyl having 1 to 5 halogen atoms, a C1-C8-halogenoalkenyl having 1 to 5 halogen atoms and a C1-C8-halogenoalkynyl having 1 to 5 halogen atoms; Z3 and Z4 are independently selected from the group consisting of a hydrogen atom, a halogen atom, a C1-C8-halogenoalkyl having 1 to 5 halogen atoms, a C1-C8-alkyl, a C2-C8-alkenyl, a C2-C8-alkynyl, a C3-C8-cycloalkyl, a C3-C8-halogenocycloalkyl having 1 to 5 halogen atoms, a C1-C8-halogenoalkenyl having 1 to 5 halogen atoms and a C1-C8-halogenoalkynyl having 1 to 5 halogen atoms; Z5 and Z6 are independently selected from the group consisting of a hydrogen atom, a C1-C8-halogenoalkyl having 1 to 5 halogen atoms, a C1-C8-alkyl, a C2-C8-alkenyl, a C2-C8-alkynyl, a C3-C8-cycloalkyl, a C3-C8-halogenocycloalkyl having 1 to 5 halogen atoms, a C1-C8-halogenoalkenyl having 1 to 5 halogen atoms and a C1-C8-halogenoalkynyl having 1 to halogen atoms; or Z4 and Z5 together with the 2 carbons to which they are attached may form a C3-C8-cycloalkyl, C3-C8-cycloalkenyl or C4-C8-cycloalkynyl, each of which may be substituted by up to 5 halogen atoms; Z7 is a non-substituted C3-C7-cycloalkyl or a C3-C7-cycloalkyl substituted by up to 10 atoms or groups independently selected from the group consisting of halogen atoms; cyano; C1-C8-alkyl; C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different; C1-C8 alkoxy C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylaminocarbonyl; and di-C1-C8-alkylaminocarbonyl; Ra is selected from the group consisting of a hydrogen atom; C1-C8-alkyl; C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkoxy-C1-C8-alkyl; C2-C8-alkenyl; C2-C8-halogenoalkenyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-alkynyl; C2-C8-halogenoalkynyl comprising up to 9 halogen atoms that can be the same or different; C3-C7-cycloalkyl; C3-C7-cycloalkyl-C1-C8-alkyl; C3-C7-halogenocycloalkyl comprising up to 9 halogen atoms that can be the same or different; formyl; C1-C8-alkylcarbonyl; C1-C8-halogenoalkylcarbonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylsulfonyl; C1-C8 halogenoalkylsulfonyl comprising up to 9 halogen atoms that can be the same or different; aryl that can be substituted by up to 5 groups Q; phenylmethylene that can be substituted by up to 7 groups Q; and phenylsulfonyl that can be substituted by up to 5 groups Q; each Q is independently selected from the group consisting of a halogen atom; cyano; isonitrile; nitro; C1-C8-alkyl; C2-C8-alkenyl; C2-C8-alkynyl; C1-C8-alkoxy; C1-C8 alkoxy-C1-C8 alkyl; C1-C8-alkoxy-C1-C8-alkoxy; C1-C8-alkylsulfanyl; C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-halogenoalkenyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-halogenoalkynyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different; C1-C8-halogenoalkylsulfanyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-halogenoalkoxy-C1-C8-alkyl comprising up to 9 halogen atoms that can be the same or different; tri(C1-C8)alkylsilyl and tri(C1-C8)alkylsilyl-C1-C8-alkyl; C1-C8-alkoxyimino; and (C1-C8-alkoxyimino)-C1-C8-alkyl; each R is independently selected from the group consisting of a hydrogen atom; halogen atom; cyano; isonitrile; nitro; amino; sulfanyl; pentafluoro-λ6-sulfanyl; C1-C8-alkylamino; di-C1-C8-alkylamino; tri(C1-C8 alkyl)silyl; C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkyl; C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-alkenyl; C2-C8-halogenoalkenyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-alkynyl; C2-C8-halogenoalkynyl comprising up to 9 halogen atoms that can be the same or different; C1-C8 alkoxy; C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different; C2-C8-alkenyloxy; C2-C8-alkynyloxy; C3-C1-cycloalkyl; C3-C1-cycloalkyl-C1-C8-alkyl; C1-C8 alkylsulfinyl; C1-C8 alkylsulfonyl; C1-C8 alkoxyimino; (C1-C8-alkoxyimino)-C1-C8-alkyl; (benzyloxyimino)-C1-C8-alkyl; aryloxy; benzyloxy; benzylsulfanyl; benzylamino; aryl; halogenoaryloxy comprising up to 9 halogen atoms that can be the same or different; C1-C8 alkylcarbonyl; C1-C8-halogenoalkylcarbonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylaminocarbonyl; and di-C1-C8-alkylaminocarbonyl;as well as its salts, N-oxides, and optically active isomers.
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