Immunomodulatory compounds for the restoration of vitamin D sensitivity in vitamin D resistant tumor cells

摘要

Provided herein are methods of restoring vitamin D sensitivity in tumor cells that are vitamin D resistant. Also provided are methods of treating, preventing or managing cancer using an immunomodulatory compound in combination with a vitamin D agent. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.

主权项

1. A method of treating, managing or breast cancer refractory to vitamin D treatment, which comprises administering to a patient having such cancer an amount of an immunomodulatory compound, or a pharmaceutically acceptable salt, or stereoisomer thereof, in combination with a vitamin D agent, wherein the immunomodulatory compound is 4-(amino)-2-(2,6-dioxo-(3-piperidyl))-isoindoline-1,3-dione, or a pharmaceutically acceptable salt, or stereoisomer thereof, or 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl) -piperidine-2,6-dione, or a pharmaceutically acceptable salt, or stereoisomer thereof.