主权项 |
1. A compound of Formula I, its tautomeric forms, stereoisomers polymorphs, salts or solvates thereof, wherein: ‘--- ’ is independently a single bond or absent; when ‘--- ’ is a single bond, ‘A’ represents carbon atom and when ‘--- ’ is absent, ‘A’ is CH or N; Y and Y′ are same or different and independently represent O or S; R1 and R2 are same or different and independently represent hydrogen, halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 haloalkyl, C2-12 haloalkenyl, C2-12 haloalkynyl, C1-C12alkoxy, C1-12 haloalkoxy, C1-C6alkoxyC1-C6alkyl, C1-C6alkoxyC1-C6alkoxyC1C3alkyl, C3-20cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n-cycloalkyl, —(CH2)n-heterocyclyl, —(CH2)n-aryl, —CH2)n-heteroaryl, —(CH2)nC(═Y)NR5R6, —(CH2)nC(═Y)OR5, —(CH2)nNR5R6, —(CH2)nOC(═Y)R5, —(CH2)nOC(═Y)OR5, —(CH2)nOC(═Y)NR5R6, —(CH2)nN(R5)C(═Y)OR6,—(CH2)nN(R5)C(═Y)NR5R6, —(CH2)nNR5C(═Y)R6, —(CH2)nC(═Y)R5, —(CH2)nYR5 wherein each methylene group may be substituted by one or more halogen atoms), —C(═Y)NR5R6, —OC(═Y)R5, —OC(═Y)NR5R6, —C(═Y)OR5, —OR5, —OC(═Y)OR5, —SR5, —NO2, —NR5R6, —N(R5)C(═Y)R6, —N(R5)—C(═Y)OR6, or —N(R5)C(═Y)NR5R6, each of which may be optionally substituted at any available position by one or more substituents Ra ; or R1 and R2 can together with the carbon atom to which they are attached form a 3 to 10 membered monocyclic ring, partially unsaturated or saturated, which may contain from one to three heteroatoms independently selected from O, S or N; the ring thus formed may be fused with one or two rings independently selected from the group comprising an aryl ring, a cycloalkyl ring, a heterocyclyl ring or monocyclic heteroaryl ring; the ring thus formed can be optionally substituted at any available position by one or more substituents Ra; R3 represents hydrogen, C1-12 alkyl, C2-12alkenyl, C2-12 alkynyl, C1-12 haloalkyl, C2-12 haloalkenyl, C2-12 haloalkynyl, C1-C6alkoxyC1-C6alkyl, C1-C6alkoxyC1-C6alkoxyC1-C3alkyl, C3-20cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n-cycloalkyl, —(CH2)n-heterocyclyl, —(CH2)n-aryl, —(CH2)n-heteroaryl, —(CH2)nYR5, —(CH2)nC(═Y)R5, —(CH2)nNR5R6, —(CH2)nC(═Y)NR5R6, —(CH2)nC(═Y)OR5, —(CH2)nOC(═Y)R5, —(CH2)nOC(═Y)OR5, —(CH2)nNR5C(═Y)R6, —(CH2)nN(R5)C(═Y)OR6, —(CH2)nN(R5)C(═Y)NR5R6, —(CH2)nOC(═Y)NR5R6, or —(CH2)nN(R5)C(═Y)NR5R6, (wherein each methylene group may be substituted by one or more halogen atoms), each of which may be optionally substituted at any available position by one or more substituents Ra; R4 represents aryl, heteroaryl, or —C(═Y)R5, each of which may be optionally substituted at any available position by one or more substituents Ra; with the proviso that when m is equal to 2 or 3, then R4 cannot be phenyl substituted with substituents selected from —OH, —OC1-4alkyl, —NH2, aminoacyl, —CH2—NH2 and aminoacylalkyl; Z represents C1-12alkyl, C2-12alkenyl, C2-12 alkynyl, C2-12 haloalkenyl, C2-12 haloalkynyl, C1-12 haloalkoxy, C1-C6alkoxyC1-C6alkoxyC1-C3alkyl, —C3-20cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n-cycloalkyl, —(CH2)n-heterocyclyl, —(CH2)n-aryl, —CH2)n-heteroaryl, —(CH2)n—NCS, —C(═Y)R5, —C(═Y)OR6, —C(═Y)NR5R6, —OC(═Y)OR5, —(CH2)nOP(═O)R5R6, —(CH2)nNHP(═O)R5R6, —(CH2)nOC(═Y)OR5, —(CH2)nC(═Y)R5, —(CH2)nC(═Y)NR5R6, or —(CH2)nC(═Y)OR5, each of which may be optionally substituted at any available position by one or more substituents Ra; T, U, V and W are same or different and independently represent hydrogen or halogen; R5and R6 are same or different and are independently selected from hydrogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 haloalkyl, C2-12 haloalkenyl, C2-12 haloalkynyl, C3-8 cycloalkyl, heterocyclyl, aryl, heteroaryl, aryloxy, —(CH2)n-cycloalkyl, —(CH2)n-heterocyclyl, —(CH2)n-aryl, —(CH2)n-heteroaryl, each of which may be optionally substituted at any available position with halogen, hydroxyl, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 alkoxy, C1-12 alkylcarbonyl, C1-12 alkoxycarbonyl, C3-8 cycloalkyl, C1-12 haloalkyl, C1-12 haloalkoxy, C2-12 haloalkenyl, aryl, heterocyclyl, heteroaryl, —(CH2)n-aryl, —(CH2)n-heterocyclyl, —(CH2)n-heteroaryl, —(CH2)n-cycloalkyl, —CN, —OR7, —NO2, —NR7R8, —N(R7)C(═Y)R8, —N(R7)C(═Y)OR8, —N(R7)C(═Y)NR7R8, —C(═Y)R7, —C(═Y)NR7R8, —OC(═Y)R7, —OC(═Y)NR7R8, —C(═Y)OR7, —OC(═Y)OR7, —SR7, —S(O)dR7, —SO2NR7R8, —NR7SO2R8, —OP(═O)R7R8, —NHP(═O)R7R8, or —P(═O)R7R8; or R5 and R6 may be joined together along with the heteroatom to which they are joined to form a heterocyclic or heteroaryl ring which may additionally contain from one to three heteroatoms independently selected from O, S or N, the ring formed may optionally be substituted with one or more substituents selected from hydrogen, halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 haloalkyl, C2-12 haloalkenyl, C2-12 haloalkynyl, C1-C6alkoxy, C1-12 haloalkoxy, C1-C6alkoxyC1-C6alkyl, C1-C6alkoxyC1-C6alkoxyC1-C3alkyl, C3-8 cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n-cycloalkyl, —(CH2)n-heterocyclyl, —(CH2)n-aryl, —(CH2)n-heteroaryl, -C1-12 alkylcarbonyl, -C1-12 alkoxycarbonyl, —CN, —CF), —OCF3 —CH2CF3; —CF2CF3, —NO2, —NR7R8, —N(R7)C(═Y)R8, —N(R7)C(═Y)OR8, —N(R7)C(═Y)NR7R8, —C(═Y)R7, —C(═Y)NR7R8, —OC(═Y)R7, —OC(═Y)NR7R8, —OC(═Y)R7, —C(═Y)OR7, —SR7, —S(O)dR7, —SO2NR7R8; —NR7SO2R8, —OP(═O)R7R8, —NHP(═O)R7R8, or —P(O)R7R8; the ring thus formed may further be fused with 3 to 7 membered unsaturated or saturated ring, which may contain from one to three heteroatoms independently selected from O, S or N, the fused ring may optionally be substituted at any available position by one or more substituents Ra; Ra is independently selected from hydrogen, halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 haloalkyl, C2-12 haloalkenyl, C2-12 haloalkynyl, oxo, C1 -12 alkoxy, C1-C6alkoxyC1-C6 alkyl, C 1-C6alkoxyC1-C6 alkoxyC1-C3alkyl, C1-12 haloalkoxy, C3-8 cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n-cycloalkyl, —(CH2)n-heterocyclyl, —(CH2)n-aryl, —(CH2)n-heteroaryl, —C1-12 alkylcarbonyl, —C1-12 alkoxycarbonyl, —CN, —YR7, —(CH2)nYR7, —NO2, ═NOR7, —NR7R8, —N(R7)C(═Y)R8, —N(R7)C(═Y)OR8, —N(R7)C(═Y)NR7R8, —C(═Y)R7, —C(═Y)NR7R8, —OC(═Y)R7, —OC(═Y)NR7R8, —C(═Y)OR7, —OC(═Y)OR7, —SR7, —S(O)dR7, —SO2NR7R8, —OP(═O)R7R8, —NHP(═O)R7R8, —P(O)R7R8, —(CH2)nCN, —YR7, —(CH2)nYR7, —NO2, ═NOR7, —(CH2)nNR7R8, —(CH2)nN(R7)C(═Y)R8, —(CH2)nN(R7)C(═Y)OR8, —(CH2)nN(R7)C(═Y)NR7R8, —(CH2)nC(═Y)R7, —(CH2)nC(═Y)NR7R8, —(CH2)nOC(═Y)R7, —(CH2)nOC(═Y)NR7R8, —(CH2)nC(═Y)OR7, —(CH2)nOC(═Y)OR7, —(CH2)nSR7, —(CH2)nS(O)dR7, —(CH2)nSO2NR7R8, —(CH2)nOP(═O)R7R8, (CH2)nNHP(═O)R7R8, or —(CH2)nP(O)R7R8; each of which may optionally be substituted at any available position by one or more substituents selected from hydrogen, halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 haloalkyl, C2-12 haloalkenyl, C2-12 haloalkynyl, oxo, C1-C12 alkoxy, C1-12 haloalkoxy, C1-C6alkoxyC1-C6alkyl, C1-C6alkoxyC1-C6alkoxyC1-C3alkyl, C3-8 cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n-cycloalkyl, —(CH2)n-heterocyclyl, —(CH2)n-aryl, —(CH2)n-heteroaryl, —C1-12 alkylcarbonyl, —C1-12 alkoxycarbonyl, —CN, —OR9, —(CH2)nOR9, —CF3, —NO2, —NR9R10, —N(R9)C(═Y)R10, —N(R9)C(═Y)OR10, —N(R9)C(═Y)NR9R10, —C(═Y)R9, —C(═Y)NR9R10, —OC(═Y)R9, —OC(═Y)NR9R10, —OC(═Y)OR9, —C(═Y)OR9, —SR9, —S(O)dR9, —SO2NR9R10; —NR9SO2R10, —OP(═O)R9R10, —NHP(═O)R9R10, —P(O)R9R10, —(CH2)nCN, —OR9, —(CH2)nOR9, —CF3, —NO2, —(CH2)nNR9R10, —(CH2)nN(R9)C(═Y)R10, —(CH2)nN(R9)C(═Y)OR10, —(CH2)nN(R9)C(═Y)NR9R10, —(CH2)nC(═Y)R9, —(CH2)nC(═Y)NR9R10, —(CH2)nOC(═Y)R9, —(CH2)nOC(═Y)NR9R10, —(CH2)nOC(═Y)OR9, —(CH2)nC(═Y)OR9, —(CH2)nSR9, —(CH2)nS(O)dR9, —(CH2)nSO2NR9R10; —(CH2)nNR9SO2R10, —(CH2)nOP(═O)R9R10, (CH2)nNHP(═O)R9R10, or —(CH2)nP(O)R9R10; R7 and R8 are independently selected from hydrogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 haloalkyl, C2-12 haloalkenyl, C3-8 cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n-cycloalkyl, —(CH2)n-heterocyclyl, —(CH2)n-aryl, or —(CH2)n-heteroaryl, each of which may be optionally substituted with halogen, hydroxyl or C1-6 alkoxy, or R7 and R8 may be joined together along with the heteroatom to which they are attached to form a heterocyclic or heteroaryl ring which may contain from one to three heteroatoms independently selected from O, S or N, each of which may be optionally substituted with halogen, hydroxyl, C1-6 alkyl or C1-6 alkoxy; R9 and R10 are independently selected from hydrogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 haloalkyl, C2-12 haloalkenyl, C3-8 cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n-cycloalkyl, —(CH2)n-heterocyclyl, —(CH2)n-aryl, or —(CH2)n-heteroaryl, each of which may be optionally substituted with halogen, hydroxyl or C1-6 alkoxy, or R9 and R10 may be joined together along with the heteroatom to which they are attached to form a heterocyclic or heteroaryl ring which may contain from one to three heteroatoms independently selected from O, S or N, each of which may be optionally substituted with halogen, hydroxyl, C1-6 alkyl or C1-6 alkoxy; m is 1, 2, 3 or 4; m′ is 0, 1, 2, 3 or 4; n is 1, 2, 3 or 4; d is 1 or 2. |