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1. A combination product for treating or ameliorating HCV (hepatitis C virus) infection or disorders or symptoms associated therewith in a subject in need thereof comprising, a HCV inhibitor compound of Formula (I) or a free acid, free base, salt, isotopologue, racemate, enantiomer, diastereomer or stereoisomer form thereof: wherein X is hydrogen, halogen, cyano, nitro, carboxyl, C1-8alkyl-carbonyl, C1-8alkoxy-carbonyl, formyl, amino, C1-8alkyl-amino, amino-carbonyl, C1-8alkyl-amino-carbonyl or C1-8alkyl-sulfonyl; Ar is pyridinyl, pyrimidinyl or pyridazinyl; Z is C1-8alkyl, C2-8alkenyl-C1-8alkyl, C2-8alkynyl-C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy-C1-8alkyl, C1-8alkoxy-carbonyl, carboxyl, C3-14cycloalkyl, C3-14cycloalkenyl, C3-14cycloalkyl-C1-8alkyl, aryl, aryl-C1-8alkyl, heteroaryl, heteroaryl-C1-8alkyl, heterocyclyl or heterocyclyl-C1-8alkyl, wherein each instance of aryl and heteroaryl is optionally substituted with one, two, three or four substituents each selected from hydroxy, cyano, nitro, halogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, hydroxy-C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, amino, C1-8alkyl-amino, C1-8alkoxy-C1-8alkyl, C1-8alkylthio, C1-8alkyl-carbonyl, C1-8alkoxy-carbonyl, C1-8alkyl-carbonyloxy or amino-sulfonyl; R1 is —SO2—N(R5)—R6; R2 is one, two, three or four substituents each selected from hydrogen, halogen, hydroxy, cyano, nitro, C1-8alkyl, hydroxy-C1-8alkyl, halo-C1-8alkyl, C2-8alkenyl, halo-C2-8alkenyl, C1-8alkoxy, halo-C1-8alkoxy, C1-8alkoxy-C1-8alkyl, C1-8alkyl-carbonyl, C1-8alkoxy-carbonyl, C1-8alkyl-carbonyloxy, C1-8alkyl-carbonyloxy-C1-8alkyl, C1-8alkyl-carbonyloxy-C1-8alkoxy, amino, C1-8alkyl-amino, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl, amino-C1-8alkoxy, C1-8alkyl-amino-C1-8alkoxy, C1-8alkoxy-C1-8alkyl-amino-C1-8alkoxy, amino-C1-8alkyl-amino-C1-8alkoxy, C1-8alkyl-amino-C1-8alkyl-amino-C1-8alkoxy, C1-8alkoxy-carbonyl-amino, carboxyl-amino, amino-carbonyl, amino-carbonyl-amino, C1-8alkyl-amino-carbonyl-amino, C1-8alkylthio, C1-8alkyl-sulfinyl, C1-8alkyl-sulfonyl, C1-8alkyl-sulfonyl-amino, C3-14cycloalkyl, C3-14cycloalkyl-C1-8alkyl, C3-14cycloalkyl-C1-8alkoxy, C3-14cycloalkyloxy, aryl, aryl-C1-8alkyl, aryl-C1-8alkoxy, aryloxy, aryl-carbonyl-amino, heteroaryl, heteroaryl-C1-8alkyl, heteroaryl-C1-8alkoxy, heteroaryloxy, heterocyclyl, heterocyclyl-C1-8alkyl, heterocyclyl-C1-8alkoxy, heterocyclyloxy or heterocyclyl-carbonyloxy, wherein each instance of C3-14cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally substituted with one, two, three or four substituents each selected from halogen, cyano, C1-8alkyl, C1-8alkoxy, C1-8alkoxy-C1-8alkyl, amino, C1-8alkyl-amino, amino-C1-8alkyl or C1-8alkyl-amino-C1-8alkyl; R3 is hydrogen or C1-8alkyl, optionally substituted on C1-8alkyl with one or more substituents each selected from halogen, hydroxy, cyano, C1-8alkoxy, amino or C1-8alkyl-amino; R4 is C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, C3-14cycloalkyl, C3-14cycloalkyl-C1-8alkyl, aryl, aryl-C1-8alkyl, heteroaryl, heteroaryl-C1-8alkyl, heterocyclyl or heterocyclyl-C1-8alkyl, wherein each instance of aryl, heteroaryl, heterocyclyl and C3-14cycloalkyl is optionally substituted with one or two substituents each selected from halogen, C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, amino or C1-8alkyl-amino; R5 is hydrogen; R6 is hydrogen, C1-8alkyl, hydroxy-C1-8alkyl, halo-C1-8alkyl, cyano-C1-8alkyl, C1-8alkoxy-C1-8alkyl, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl, C1-8alkyl-carbonyl, C1-8alkoxy-carbonyl, C3-14cycloalkyl, C3-14cycloalkyl-C1-8alkyl, aryl, aryl-C1-8alkyl, heteroaryl, heteroaryl-C1-8alkyl, heterocyclyl or heterocyclyl-C1-8alkyl, wherein each instance of aryl, heteroaryl, heterocyclyl and C3-14cycloalkyl is optionally substituted with one or two substituents each selected from halogen, C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, amino or C1-8alkyl-amino; and and a HCV protease inhibitor or a free acid, free base, salt, isotopologue, racemate, enantiomer, diastereomer or stereoisomer form thereof selected from: tert-butyl 1-((2S)-1-(1-amino-1,2-dioxohexan-3-ylamino)-4-methyl-1-oxopentan-2-ylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate, (S)-2-acetamido-N-((S)-1-((S)-5-guanidino-1-oxopentan-2-ylamino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide, tert-butyl (1S)-2-((2S)-2-(4-amino-1-cyclopropyl-3,4-dioxobutan-2-ylcarbamoyl)indolin-1-yl)-1-cyclohexyl-2-oxoethylcarbamate, (3S,18S)-N-[(3S)-1-amino-1,2-dioxohexan-3-yl]-18-cyclohexyl-16,19-dioxo-3,4-dihydro-1H-7,2-(eboxyheptanoiminoethano)isoguinoline-3-carboxamide, tert-butyl (3S)-1-((2S)-1-(4-amino-1-cyclopropyl-3,4-dioxobutan-2-ylamino)-4-methyl-1-oxopentan-2-yl)-2-oxoazonan-3-ylcarbamate, (2S)-isopropyl 2-(3-((3S)-1-((2S)-1-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-ylamino)-4-methyl-1-oxopentan-2-yl)-2-oxoazonan-3-yl)ureido)-3,3-dimethylbutanoate, tert-butyl (1S)-2-((1S,3aR,6aS)-1-(4-amino-1-cyclopropyl-3,4-dioxobutan-2-ylcarbamoyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-1-cyclohexyl-2-oxoethylcarbamate, tert-butyl (S)-2-((1R,2S,5S)-2-((S)-4-amino-1-cyclopropyl-3,4-dioxobutan-2-ylcarbamoyl)-6,6,7,7-tetramethyl-3-azabicyclo[3.2.0]heptan-3-yl)-1-cyclohexyl-2-oxoethylcarbamate, (2S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-((S)-2-(3-cyclohexylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-N-((S)-4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-N-((R)-4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((R)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((S)-5-cyclopropyl-1-(cyclopropylamino)-1,2-dioxopentan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((R)-5-cyclopropyl-1-(cyclopropylamino)-1,2-dioxopentan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-N-((S)-1-(allylamino)-5-cyclopropyl-1,2-dioxopentan-3-yl)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-N-((S)-4-(allylamino)-1-cyclopropyl-3,4-dioxobutan-2-yl)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-N-((S)-4-(allylamino)-1-cyclopropyl-3,4-dioxobutan-2-yl)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-2-(1-methylcyclohexyl)acetyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-2-(1-methylcyclohexyl)acetyl)-N-((S)-5-cyclopropyl-1-(cyclopropylamino)-1,2-dioxopentan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-2-(1-methylcyclohexyl)acetyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-N-((S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl)-3-((S)-3,3-dimethyl-2-(3-(1-((4-methyltetrahydro-2H-pyran-4-ylsulfonyl)methyl)cyclohexyl)ureido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-3-[N-({1-[(2S)-3,3-dioxido-1,3-oxathiolan-2-yl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-[(3S)-1,2-dioxo-1-(prop-2-en-1-ylamino)heptan-3-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)- N-[(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]-3-[N-({1-[(2R)-1,1-dioxidotetrahydrothiophen-2-yl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-3-[N-({1-[(2R)-1,1-dioxidotetrahydrothiophen-2-yl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-[(3S)-1,2-dioxo-1-(prop-2-en-1-ylamino)heptan-3-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, (1R,2S,5S)-N-[(2S)-1-cyclopropyl-3,4-dioxo-4-(prop-2-en-1-ylamino)butan-2-yl]-3-[N-({1-[(2S)-1,1-dioxidotetrahydro-2H-thiopyran-2-yl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, or (1R,2S,5S)-3-[N-({1-[(3R)-4,4-dioxido-1,4-oxathian-3-yl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-[(3S)-1,2-dioxo-1-(prop-2-en-1-ylamino)heptan-3-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide. |
