发明名称 |
Non-invasive reagentless glucose determination |
摘要 |
Non-invasive apparatus and method for determining and monitoring glucose concentrations in human subjects. Glucose level is estimated through the effect of glucose on biological cells with glucose dependencies, e.g., red blood cells. The invention is based on the interaction of such cells with oscillating electric field gradients. The response of biological cells depends on factors including shape, size, and electrical charge distribution. The field gradient causes the cells to undergo characteristic motion which is detected by light beam scattering. The autocorrelation of the scattered light is computed, and the Fourier transform (FT) is performed to produce a characteristic velocity spectrum in which the peaks are characteristic of the cell “bio-electrical” states. The glucose level is estimated through measurements of changes of FT with changes in glucose levels after calibration with standard glucose methods. |
申请公布号 |
US8843186(B2) |
申请公布日期 |
2014.09.23 |
申请号 |
US201213683924 |
申请日期 |
2012.11.21 |
申请人 |
|
发明人 |
Halaka Folim G. |
分类号 |
A61B5/1455;A61B5/00;A61B5/05;A61B5/145 |
主分类号 |
A61B5/1455 |
代理机构 |
|
代理人 |
Kraft Clifford |
主权项 |
1. A non-invasive glucose measuring apparatus comprising:
an elongated housing configured to present an oscillating, non-uniform electric field onto a predetermined part of a human body; said housing containing first and second electrodes, the first electrode being arcuate; the second electrode being substantially centered in said arcuate first electrode, wherein said electrodes are configured to generate the non-uniform electric field near the arcuate electrode and the center electrode when the electrodes are connected to an oscillating electrical power source; a light source said elongated housing also configured to present a collimated light beam generated by the light source onto said predetermined part and to direct light scattered from said part into a detector; a processor in communication with said detector, said processor executing a program that produces an autocorrelation related to said scattered light; said program comparing said autocorrelation, or a function of said autocorrelation, against a predetermined calibration to determine a glucose level. |
地址 |
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