| 发明名称 |
Method and apparatus for detecting pharmaceuticals in a sample |
| 摘要 |
A method and apparatus for measuring a vitamin K antagonizing anticoagulant present in a sample (116), arranged to: irradiate (304) the sample (116) with light from a light source (114) for exciting the anticoagulant through its absorption of the light, the excitation of the sample (116) resulting in a fluorescent emission from the sample (116); measure (306) the fluorescent emission from the sample (116); determine (308) a fluorescence lifetime (T1) of the fluorescent emission of the sample (116); determine (310) an intensity (A1) of the fluorescent emission at the fluorescence lifetime (T1); and determine (312) a amount (c) of the anticoagulant, as a function of the intensity (A1) of the fluorescent emission at the fluorescence lifetime (T1). |
| 申请公布号 |
US8841633(B2) |
申请公布日期 |
2014.09.23 |
| 申请号 |
US201013263399 |
申请日期 |
2010.03.25 |
| 申请人 |
|
发明人 |
Nicholls Ian A;Karlsson Bjorn C.G.;Rosengren Annika M;Andersson Per Ola |
| 分类号 |
G01J1/58;G01N21/64 |
主分类号 |
G01J1/58 |
| 代理机构 |
Ladas & Parry LLP |
代理人 |
Ladas & Parry LLP |
| 主权项 |
1. A method for measuring a vitamin K antagonizing anticoagulant present in a sample (116), the method comprising:
irradiating (304) the sample (116) with light from a light source (114) for exciting the anticoagulant through its absorption of the light, the excitation of the sample (116) resulting in a fluorescent emission from the sample (116), measuring (306) the fluorescent emission from the sample (116), determining (308) a fluorescence lifetime (τ1) of the fluorescent emission of the sample (116), determining (310) an intensity (A1) of the fluorescent emission at the fluorescence lifetime (τ1), and determining (312) an amount (c) of the anticoagulant, as a function of the intensity (A1) of the fluorescent emission at the fluorescence lifetime (τ1). |
| 地址 |
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