Body cavity foams

摘要

The invention relates to an alcohol-free cosmetic or therapeutic foam carrier comprising water, a hydrophobic organic carrier, a foam adjuvant agent, a surface-active agent and a gelling agent. The cosmetic or therapeutic foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble therapeutic and cosmetic agents.

主权项

1. A device for administration of a foamable composition into a body cavity, comprising an aerosol container, a valve, an insert applicator and a foamable composition for application into said body cavity, which upon release from said aerosol container provides an expanded foam suitable for topical administration;
wherein the foamable composition comprises a propellant and a therapeutic composition being substantially free of lower alcohols wherein the therapeutic composition comprises: at least one organic carrier selected from a hydrophobic organic carrier, an emollient, a polar solvent, and mixtures thereof, at a concentration of about 70% to about 99% by weight of the therapeutic composition; at least one surface active agent at a concentration of about 0.2% to about 5% by weight of the therapeutic composition; at least one active agent; and at least one polymeric gelling agent at a concentration of about 0.01% to about 5% by weight of the therapeutic composition; wherein the propellant is a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the foamable composition; wherein the surface active agent is a non-ionic surface active agent or a mixture of at least one non ionic surface active agent and at least one ionic surface active agent in a ratio of about 20:1 or greater than 20:1. wherein upon release from the container the composition forms a breakable foam that collapses upon application of shear force; and wherein the breakable foam stays stable as a foam for at least about 3 minutes at about 37° C. after being dispensed from the container.