Therapeutic nuclease compositions and methods

摘要

Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.

主权项

1. A polypeptide comprising human RNase 1 operatively coupled with or without a linker to an Fc domain, and human DNase I operatively coupled with or without a linker to the Fc domain, wherein the Fc domain is a human immunoglobulin Fc domain or a mutant human immunoglobulin Fc domain.