| 发明名称 | Pharmaceutical composition and method for regulating abnormal cellular proliferation | ||
| 摘要 | A method of treating a disease associated with a cell population which proliferates abnormally in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of at least one modulator capable of modulating in the cell population a level and/or activity of a polypeptide having an amino acid sequence at least 60 percent similar to SEQ ID NO: 5, as determined using the Standard protein-protein BLAST [blastp] software of the NCBI. | ||
| 申请公布号 | US8841266(B2) | 申请公布日期 | 2014.09.23 |
| 申请号 | US200612085023 | 申请日期 | 2006.11.16 |
| 申请人 | Tel Hashomer Medical Research Infrastructure and Services Ltd.;The United States of America as represented by the Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer | 发明人 | Izraeli Shai;Kirsch Ilan R.;Erez Ayelet;Campaner Stefano |
| 分类号 | A01N43/04;C12P19/34;C12N15/63;C07H21/02;C07H21/04 | 主分类号 | A01N43/04 |
| 代理机构 | Browdy and Neimark, PLLC | 代理人 | Browdy and Neimark, PLLC |
| 主权项 | 1. A method of treating a cancer comprising administering to a subject in need thereof a therapeutically effective amount of at least one modulator which decreases or eliminates a level and/or activity of a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 5, thereby treating the cancer in the subject, wherein said modulator is selected from the group consisting of an siRNA molecule which induces degradation or inhibits translation of an mRNA encoding said polypeptide and an antisense polynucleotide which hybridizes with an mRNA encoding said polypeptide. | ||
| 地址 | Ramat-Gan IL | ||