PSA capture agents, compositions, methods and preparation thereof

摘要

Disclosed herein are novel synthetic prostate specific antigen (PSA)-targeted capture agents that specifically bind PSA. In certain embodiments, these PSA capture agents are biligand or triligand capture agents containing two or three target-binding moieties, respectively.

主权项

1. A synthetic detection agent comprising a multi-ligand prostate specific antigen (PSA)-targeted capture agent that specifically binds PSA in serum, wherein the capture agent is a triligand; wherein the triligand comprises an anchor ligand, a secondary ligand, and a tertiary ligand; wherein the linkage between one or more of the anchor ligand, secondary ligand, and tertiary ligand comprises a 1,5-substituted-1,2,3-triazole residue (Tz5) or a 1,4-substituted-1,2,3-triazole residue (Tz4):