Human monoclonal antibodies to the thyrotropin receptor which act as antagonists

摘要

The invention provides an isolated antibody for the TSHR which is an antagonist of TSH. The invention also relates to methods of using antibodies of the invention.

主权项

1. An isolated human monoclonal or recombinant antibody for the Thyroid Stimulating Hormone Receptor (TSHR), wherein said antibody is an antagonist of Thyroid Stimulating Hormone (TSH), and has a binding affinity for full length human TSHR of about 109 L/mol, and
wherein said antibody comprises a VH region comprises the following Complement Determining Regions (CDRs):a) SNYMS (CDR1)(SEQ ID NO: 1);b) VTYSGGSTSYADSVKG (CDR2)(SEQ ID NO: 2); andc) GGRYCSSISCYARSGCDY (CDR3)(SEQ ID NO: 3); and said antibody comprises a VL region comprises the following CDRs:a) RASQSISNYLN (CDR1)(SEQ ID NO: 4);b) AASSLQS (CDR2)(SEQ ID NO: 5); andc) QQSYSSPSTT (CDR3)(SEQ ID NO: 6).