Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues

摘要

Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component that includes an Glucocorticoid Derivative which, upon delivery to the posterior segment of a mammalian eye, does not significantly diffuse to the anterior segment of said eye. Methods of making and using the present materials are also described.

主权项

1. A method of treating a condition of a mammalian eye selected from the group consisting of retinal arterial occlusive disease, retinal vein occlusion, central retinal vein occlusion, disseminated intravascular coagulopathy, branch retinal vein occlusion, ocular ischemic syndrome, retinal arterial microaneurysms, Coat's disease, parafoveal telangiectasis, hemiretinal vein occlusion, papillophlebitis, central retinal artery occlusion, branch retinal artery occlusion the method comprising the step of administering to the eye a composition comprising a therapeutically effective amount of hyaluronic acid and a glucocorticoid derivative comprising an acyl group linked to C17 via an ester linkage.