发明名称 |
METHOD OF PRODUCING BIOLOGICALLY ACTIVE VITAMIN K DEPENDENT PROTEINS BY RECOMBINANT METHODS |
摘要 |
The invention relates to commercially viable methods for producing biologically active vitamin K dependent proteins, particularly Factor IX. Factor IX is produced at a level of at least about 15mg/L and is at least 25% biologically active. The method relies upon co-expression of one or more of paired basic amino acid converting encyme (PACE), vitamin K dependent epoxide reductase (VKOR) and vitamin K dependent ³-glutamyl carboxylase (VKGC) at a preferred ratio so that the vitamin K dependent protein is efficiently produced and processed by a recombinant cell. |
申请公布号 |
PT1969127(E) |
申请公布日期 |
2014.09.23 |
申请号 |
PT20060848864T |
申请日期 |
2006.12.21 |
申请人 |
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;CNJ HOLDINGS, INC |
发明人 |
MICHAEL J. GRIFFITH;WILLIAM N. DROHAN;JOHN R. TAYLOR;DARREL W. STAFFORD |
分类号 |
C12N15/57;C12P21/02 |
主分类号 |
C12N15/57 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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