| 发明名称 | Antibodies to human GDF8 | ||
| 摘要 | The present invention provides isolated human or humanized antibodies or antigen-binding fragments thereof which specifically bind to Growth and Differentiation Factor-8 (GDF8) and block GDF8 activity. The antibodies and antibody fragments of the present invention may be used in therapeutic methods for treating conditions or disorders which are ameliorated or improved by inhibition of GDF8. | ||
| 申请公布号 | US8840894(B2) | 申请公布日期 | 2014.09.23 |
| 申请号 | US201113115170 | 申请日期 | 2011.05.25 |
| 申请人 | Regeneron Pharmaceuticals, Inc. | 发明人 | Stitt Trevor;Latres Esther |
| 分类号 | A61K39/395;C07K16/22;A61P21/06;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Merchant & Gould PC | 代理人 | Merchant & Gould PC |
| 主权项 | 1. An isolated human antibody or antigen-binding fragment thereof that specifically binds to, or blocks the biological activity of wild-type mature human GDF8 comprising SEQ ID NO: 340, but (a) does not bind to, or block the biological activity of a chimeric GDF8/TGFβ1 construct having amino acids 48-72 of mature human GDF8 replaced with the corresponding amino acid sequence of TGFβ1, and (b) does not bind to an isolated polypeptide consisting of amino acids 48-72 of SEQ ID NO: 340; and wherein the antibody or antigen-binding fragment comprises a heavy and light chain variable domain amino acid sequence pair (HCVR/LCVR) selected from the group consisting of SEQ ID NOs: 114/122; 360/368; and 376/384. | ||
| 地址 | Tarrytown NY US | ||