| 发明名称 | Humanized AXL antibodies | ||
| 摘要 | The present invention refers to monoclonal humanized antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity. | ||
| 申请公布号 | US8841424(B2) | 申请公布日期 | 2014.09.23 |
| 申请号 | US201013320060 | 申请日期 | 2010.05.11 |
| 申请人 | U3 Pharma GmbH | 发明人 | Wirtz Peter;Ruhe Jens;Takizawa Takeshi;Takayama Tomoko |
| 分类号 | C07K16/40;C07K16/00;A61K39/395 | 主分类号 | C07K16/40 |
| 代理机构 | Rothwell, Figg, Ernst & Manbeck, P.C. | 代理人 | Rothwell, Figg, Ernst & Manbeck, P.C. |
| 主权项 | 1. A monoclonal humanized antibody that binds to the extracellular domain of AXL and at least partially inhibits AXL activity, wherein said antibody comprises a heavy chain amino acid sequence selected from the group consisting of SEQ ID NO:67 to SEQ ID NO:72, or at least the variable domain thereof, or a variable domain of a heavy chain amino acid sequence selected from the group consisting of SEQ ID NO:114 to SEQ ID NO:120 and a light chain amino acid sequence selected from the group consisting of SEQ ID NO:55 to SEQ ID NO:60, or a variable domain of a light chain amino acid sequence selected from the group consisting of SEQ ID NO:83 to SEQ ID NO:113. | ||
| 地址 | Martinsried DE | ||