| 发明名称 |
Pharmaceutical formulation |
| 摘要 |
The invention relates to aqueous pharmaceutical formulations comprising human growth hormone, histidine, poloxamer, phenol, and mannitol. |
| 申请公布号 |
US8841252(B2) |
申请公布日期 |
2014.09.23 |
| 申请号 |
US200912575886 |
申请日期 |
2009.10.08 |
| 申请人 |
Novo Nordisk Health Care AG |
发明人 |
Bjørn Søren;Sørensen Hans Holmegaard;Langballe Peter;Larsen Silke Møller;Ebbehøj Kristen;Hansen Birthe Lykkegaard |
| 分类号 |
A61K38/27;A61P5/06;A61P3/04 |
主分类号 |
A61K38/27 |
| 代理机构 |
|
代理人 |
Wilk-Orescan Rosemarie R. |
| 主权项 |
1. An aqueous pharmaceutical formulation comprising a) about 1 mg/ml to about 15 mg/ml of human growth hormone (hGH), b) histidine in an amount of about 0.05-about 0.5 mg per mg hGH, c) Poloxamer 188 in an amount of about 0.1-about 2 mg per mg hGH, d) mannitol in an isotonicity conferring amount, and e) phenol in an amount that confers a preservative effect, wherein the formulation has a pH 6.0-6.2, and wherein the hGH is dissolved in said formulation. |
| 地址 |
Zurich CH |
