Patterned nanosubstrates made by directed self assembly of amphiphilic molecules

摘要

Nanoscale patterns prepared by lithography are used to direct the self-assembly of amphiphilic molecules to form patterned nanosubstrates having a desired distribution of chemical functional moieties. These patterns can be fabricated over a large area and require no special limitations on the chemistry the assembled amphiphiles. Hydrophilic/hydrophobic patterns can be created and used to direct the deposition of a single functional component to specific regions of the surface or to selectively assemble polymer blends to desired sites in a one step fashion with high specificity and selectivity. The selective deposition of functional moieties on a patterned surface can be based on electrostatic forces, hydrogen bonding, or hydrophobic interactions. The methods and patterned nanosubstrates of the invention can be used in the assembly of functional polymer systems, polyelectrolytes, biomolecules, conducting polymers, colloids and nanoparticles, and find wide technological applications in biosensors, biochips, photonics and electronics.

主权项

1. A method of fabricating a patterned nanosubstrate, the method comprising:
(a) providing a substrate coated with a resist layer; (b) forming a nanoscale pattern in the resist layer by lithography, wherein the pattern comprises one or more first regions essentially devoid of resist and one or more second regions comprising resist; (c) plasma treating the one or more first regions; (d) forming a monolayer of first amphiphiles in the one or more first regions by self assembly; (e) removing resist from the one or more second regions; and (f) coupling a functional agent to distal ends of at least a portion of the first amphiphiles, wherein the functional agent is a biomolecule, cell, or functionalized nanoelement, and wherein said coupling is performed in less than 1 minute.