摘要 |
Provided herein are Aminopurine Compounds having the following structure:
wherein R 1 , R 2 and and R 3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof. |
申请人 |
SIGNAL PHARMACEUTICALS LLC;PHARMACOPEIA, LLC |
发明人 |
ALBERS, RONALD;AYALA, LETICIA;CLAREEN, STEVEN S.;DELGADO MEDEROS, MARIA M.;HILGRAF, ROBERT;HEGDE, SAYEE;KOIS, ADAM;PLANTEVIN-KRENITSKY, VERONIQUE;MCCARRICK, MEG;NADOLNY, LISA;PALANKI, MOORTHY;SAHASRABUDHE, KIRAN;SAPIENZA, JOHN;SATOH, YOSHITAKA;SLOSS, MARIAN;SUDBECK, ELISE;WRIGHT, JONATHAN;COLE, ANDREW G.;HENDERSON, IAN;HUGHES, KEVIN |