发明名称 Heterocyclic compounds as autotaxin inhibitors
摘要 Compounds of the formula (I), in which Het, R, X, Y, R1 and p have the meanings indicated in claim 1, are autotaxin inhibitors and can be employed for the treatment of tumors.
申请公布号 US8841324(B2) 申请公布日期 2014.09.23
申请号 US201013259464 申请日期 2010.03.03
申请人 Merck Patent GmbH 发明人 Staehle Wolfgang;Schiemann Kai;Schultz Melanie
分类号 A01N43/40;A61K31/445;A01N43/38;A61K31/40;A61K31/405;A01N43/52;A61K31/415;C07D403/00;C07D211/32;C07D249/18;C07D403/12;C07D401/12;C07D209/08;C07D413/12;C07D231/56;C07D413/06;C07D263/58 主分类号 A01N43/40
代理机构 Millen, White, Zelano & Branigan, P.C. 代理人 Millen, White, Zelano & Branigan, P.C.
主权项 1. A compound of formula I in which R1 denotes H, A, Hal, OR3, N(R3)2, N═CR3N(R3)2, SR3, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)mA, —[C(R3)2]nN(R3)2, O[C(R3)2]pN(R3)2, S[C(R3)2]nN(R3)2, —NR3[C(R3)2]nN(R3)2, NHCON(R3)2, CON(R3)2, CONR3[C(R3)2]nN(R3)2 or COA, R3 denotes H or A, X denotes O, NH or CH2, Y denotes CH2, CH2O or is absent, R denotes q denotes 2 or 3, t denotes 1 or 2, R4 denotes H, A or phenyl, Het denotes A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7H atoms are optionally replaced by OH, F, Cl and/or Br, and/or in which one or two CH2 groups optionally replaced by O, NH and/or S, or a cyclic alkyl having 3-7 C atoms, Hal denotes F, Cl, Br or I, n denotes 0, 1, 2 or 3, m denotes 0, 1 or 2, p denotes 0, 1, 2, 3, 4 or 5, or a pharmaceutically acceptable salt or stereoisomer thereof.
地址 Darmstadt DE