| 摘要 |
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis. |
| 主权项 |
1. A chemical entity selected from the compounds of Formula (I)wherein
Z is CH; Y is N; R1 is:
a) —(CH2)2OCH3, —(CH2)2SCH3, or C1-8alkyl, each independently unsubstituted or substituted with —OH or —CF3;b) —(CH2)0-2—Ar1, —CHR2—Ar1, —(CH2)0-2—Ar2, each of said Ar1 and Ar2 independently unsubstituted or substituted with halo, —CH3, —OCH3,Ar1 is a 6-membered aromatic carbocyclic ring,Ar2 is a 5 to 6-membered heteroaromatic ring containing N, S or O; orc) cycloalkyl, —(CH2)-(monocyclic cycloalkyl), —(CH2)-(bridged polycyclic cycloalkyl)0-1, —(CHR2)-(monocyclic cycloalkyl), —(CH2)-(fused cycloalkyl), —(CH2)-(bridged monocyclic cycloalkyl), —(CH2)0-1-tetrahydrofuranyl, and —(CH2)0-1-tetrahydropyranyl, each independently unsubstituted or substituted with one, two, or three C1-4alkyl substituents; R2 is —C1-4alkyl; where Ra, Rb, and Rc are each independently H or C1-3alkyl; andpharmaceutically acceptable salts of compounds of Formula (I). |
