IGA1 protease polypeptide agents and uses thereof

摘要

Polypeptide agents useful in the treatment of IgA1 deposition diseases and methods of using such polypeptide agents. Methods of screening for inhibitors of IgA1 proteases and agents that inhibit IgA1 proteases are also disclosed.

主权项

1. An IgA1 protease polypeptide comprising a polypeptide backbone whose amino acid sequence shares at least 75% overall sequence identity with SEQ ID NO: 24 and comprises an N-terminal chymotrypsin-like protease domain and subdomains-2 to −4, wherein the IgA1 protease polypeptide has a C-terminal truncation after the subdomain-4, so that it lacks sequences C-terminal to the truncation, which IgA1 protease polypeptide is less immunogenic than full-length polypeptide lacking the C-terminal truncation.