Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections

摘要

A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated formulation of aztreonam lysinate delivered as an aerosol or dry powder formulation.

主权项

1. A formulation package comprising:
a) an aztreonam lysinate suitable for inhalation and in dry or lyophilized powder form prepared from α-aztreonam; and b) a diluent; wherein the aztreonam lysinate in dry or lyophilized powder form and the diluent are stored separately.