发明名称 |
TOLL-LIKE RECEPTOR 4 (TLR4)-NEUTRALIZING ANTIBODIES |
摘要 |
<p>This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not complexed with MD-2. The invention further provides methods of using the monoclonal antibodies as therapeutics. This invention also provides soluble chimeric proteins, methods of expressing and purifying soluble chimeric proteins, and methods of using soluble chimeric proteins as therapeutics, in screening assays and in the production of antibodies.</p> |
申请公布号 |
CA2548990(C) |
申请公布日期 |
2014.09.23 |
申请号 |
CA20042548990 |
申请日期 |
2004.12.10 |
申请人 |
NOVIMMUNE SA |
发明人 |
ELSON, GREG CHRISTOPHER ANDREW |
分类号 |
C07K16/28;A61K38/17;A61K39/395;A61P11/06;A61P19/02;A61P31/00;A61P37/00;C07K14/705;C07K19/00;C12N5/10;C12N15/10;C12N15/79;G01N33/50 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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