| 主权项 |
1. A method of treating Crohn's disease or inflammatory bowel disease (IBD) comprising administering an effective amount of noscapine or a noscapine analog or salt thereof to a subject in need thereof wherein the noscapine analog is a compound comprising Formula A: or pharmaceutically acceptable salts, prodrugs or derivatives thereof; wherein Z is a halogen, nitro, or nitrogen wherein nitrogen may be optionally substituted with R4; X is carbonyl or methylene (CH2) optionally substituted with R4; R1, R2, and R3 are each independently an alkoxy optionally substituted with one or more R4; R4 is independently selected from alkyl, alkenyl, alkanoyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, dialkylamino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl, and heterocyclyl wherein R4 is optionally substituted with R5; R5 is selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, propyl, tert-butyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, and heterocyclyl. |
