发明名称 |
Fremgangsmåde til behandling og forebyggelse af sekundær hyperparathyroidisme |
摘要 |
A method of treating elevated blood levels of iPTH by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in a patient by administering, as necessary, both Vitamin D repletion and Vitamin D hormone replacement therapies, is disclosed. The blood concentrations of 25-hydroxyvitamin D are increased to and maintained at or above 30 ng/mL, and blood concentrations of 1,25-dihydroxyvitamin D are increased to or maintained within a patient's normal historical physiological range for 1,25-dihydroxyvitamin D without causing substantially increased risk of hypercalcemia, hyperphosphatemia or over suppression of plasma iPTH in the patient. The blood levels of 25-hydroxyvitamin D are maintained at or above 30 ng/mL between doses of Vitamin D repletion therapies, and the blood levels of 1,25-dihydroxyvitamin D are maintained in the patient's normal historical physiological range between doses of Vitamin D hormone replacement therapies. In one aspect, the disclosure includes methods wherein the blood concentration of 25-hydroxyvitamin D during treatment comprises predominantly 25-hydroxyvitamin D 3 , and/or wherein the method includes administering predominantly or solely 25-hydroxyvitamin D 3 for 25-hydroxyvitamin D repletion and/or maintenance. |
申请公布号 |
DK2037936(T3) |
申请公布日期 |
2014.09.22 |
申请号 |
DK20070840277T |
申请日期 |
2007.06.21 |
申请人 |
OPKO RENAL, LLC;OPKO IP HOLDINGS II, INC. |
发明人 |
PETKOVICH, P. MARTIN;BISHOP, CHARLES, W.;CRAWFORD, KEITH, H.;MESSNER, ERIC, J.;HELVIG, CHRISTIAN, F. |
分类号 |
A61K31/59;A61P5/20 |
主分类号 |
A61K31/59 |
代理机构 |
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