| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to immunology. What is presented is a recovered human integrin ?5?1 monoclonal antibody. The antibody is characterised by the fact that it contains 6 CDR, 3 CDR from a light chain and 3 CDR from a heavy chain. A nucleic acid (NA) coding the antibody according to the invention, an expression vector containing a NA molecule, a host cell containing the vector, and a method for preparing the antibody on the basis of the cell are described. There are disclosed: a composition and a method for growth inhibition of the tumour cells expressing human integrin ?5?1 on the basis of the antibody. What is described is a version of the method for growth inhibition of the tumour cells expressing human integrin ?5?1 using the composition.EFFECT: invention provides the new antibodies with high (approximately nm, as measured by FACS) binding affinity for human integrin ?5?1 that can find application in medicine in therapy of the tumours mediated by integrin ?5?1 expression.13 cl, 36 dwg, 3 tbl, 11 ex |
