CAPSULE FORMULATION OF PIRFENIDONE AND PHARMACEUTICALLY ACCEPTABLE EXCIPIENTS

摘要

PROBLEM TO BE SOLVED: To provide a pharmaceutical formulation of pirfenidone with advantageous therapeutic effect, particularly, a pharmaceutical formulation of pirfenidone which can induce and sustain a desirable pharmacokinetic response; and to also provide a method for treating a fibrotic condition and other cytokine-mediated disorder using the above formulation.SOLUTION: The invention provides a capsule having a pharmaceutical formulation of 5-methyl-1-phenyl-2-(1H)-pyridone (pirfenidone), wherein the pharmaceutical formulation comprises 5 to 30 mass% of pharmaceutically acceptable excipients and 70 to 95 mass% of pirfenidone.