| 摘要 |
PROBLEM TO BE SOLVED: To provide a kinase antagonist.SOLUTION: Provided is a new compound as the antagonist of PI3 kinase, PI3 kinase and tyrosine kinase, PD kinase and mTOR or PI3 kinase, mTOR and tyrosine kinase. In one embodiment, this invention provides a new kinase antagonist as a PI3-kinase affinity pocket binding antagonist (e.g., a P3 kinase affinity pocket binding pyrazolopyrimidine antagonist or a PI3-kinase affinity pocket binding pyrrolopyrimidine antagonist). The PI3-kinase affinity pocket binding antagonist is a compound having a PI3-kinase affinity pocket binding part. The PI3-kinase affinity pocket binding pyrazolopyrimidine compound is a substituted pyrazolopyrimidine compound having a PI3-kinase affinity pocket binding part. |
