| 主权项 |
1. A compound of formula (I) whereinis selected from the group consisting of, R1 is selected from the group consisting of cyano, C1-6alkyl, -(hydroxy substituted C1-4alkyl), chloro substituted C1-4alkyl, fluoro substituted C1-4alkyl, C2-4alkenyl, chloro substituted C2-4alkenyl, fluoro substituted C2-4alkenyl, C2-4alkynyl, —(C1-4alkyl)-O—(C1-4alkyl), —(C1-4alkyl)-SO—(C1-4alkyl), —(C1-4alkyl)-SO2—(C1-4alkyl), —(C1-4alkyl)-NRARB, —(C1-4alkyl)-NRA—C(O)—(C1-4alkyl), —(C1-4alkyl)-NRA—SO2—(C1-4alkyl), —C(O)OH, —C(O)O—(C1-4alkyl), —C(O)—(C1-4alkyl), —C(O)—NRARB, C3-8cycloalkyl, —(C1-4alkyl)-(C3-8cycloalkyl), aryl and —(C1-2alkyl)-(aryl); wherein RA and RB are each independently selected from the group consisting of hydrogen and C1-4alkyl; R2 is selected from the group consisting of hydrogen, halogen and C1-4alkyl; R3 is selected from the group consisting of hydrogen, chloro and fluoro; R4 and R5 are each independently selected from the group consisting of hydrogen, halogen, cyano, C1-4alkyl, chloro substituted C1-4alkyl, fluoro substituted C1-4alkyl, C2-4alkenyl, chloro substituted C2-4alkenyl, fluoro substituted C2-4alkenyl, C2-4alkynyl, chloro substituted C2-4alkynyl, fluoro substituted C2-4alkynyl, C1-4alkoxy, fluoro substituted C1-4alkoxy, —O—(C1-4alkyl)-O—(C1-4alkyl), —(C1-4alkyl)-O—(C1-4alkyl), —(C1-4alkyl)-SO2—(C1-4alkyl), —(C2-4alkenyl)-SO2—(C1-4alkyl), —C(O)—NRCRD, —O-(aryl) and —O—(C1-2alkyl)-aryl; wherein RC and RD are each independently selected from the group consisting of hydrogen and C1-4alkyl; provided that at least one of R4 or R5 is selected from the group consisting of hydrogen, chloro and fluoro; alternatively, whereinR4 and R5 may be taken together with the carbon atoms to which they are bound to form a ring structure selected from the group consisting of W is selected from the group consisting of C(R9); wherein R9 is selected from the group consisting of hydrogen, fluoro and bromo; alternatively, whereinW may be N;
R6 and R7 are each independently selected from the group consisting of hydrogen, halogen, cyano, C1-6alkyl, chloro substituted C1-4alkyl, fluoro substituted C1-4alkyl, bromo substituted C1-4alkyl, C1-4alkoxy and fluoro substituted C1-4alkoxy; alternatively, whereinand W is C(R9), R6 and R7 may be taken together with the carbon atoms to which they are bound to form R8 is selected from the group consisting of hydrogen, halogen, cyano, C1-6alkyl, chloro substituted C1-4alkyl, fluoro substituted C1-4alkyl, bromo substituted C1-4alkyl, C1-4alkoxy, fluoro substituted C1-4alkoxy and —(C1-4alkyl)-C(O)OH; R0 is selected from the group consisting of —CH2OH and —C(O)OH; or a pharmaceutically acceptable salt thereof. |
