| 摘要 |
The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds. |
| 主权项 |
1. A composition comprising a compound of Formula I: wherein R1, R2, R3, R4, and R5 are independently selected for each occurrence from the group consisting of hydrogen, halogen, alkyl, aryl, alkoxy, aryloxy, alkylthiol, arylthiol, CN, and NO2; and wherein R10 is selected from the group consisting of substituted or unsubstituted alkyl, cycloalkyl, aryl, heteroaryl and alkenyl. |
