发明名称 |
Compositions with a Rheological Modifier to Reduce Dissolution Variability |
摘要 |
The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided. |
申请公布号 |
US2014275147(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
US201414214057 |
申请日期 |
2014.03.14 |
申请人 |
Durect Corporation |
发明人 |
Yum Su Il;Chao Wendy;Su Huey-Ching;Fu Roger;Zamloot Michael S.;Bratin Karl;Shanker Ravi M. |
分类号 |
A61K31/485;A61K31/4458;A61K31/137 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising:
a pharmacologically active agent; about 35% by weight to about 45% by weight, based on total weight of the composition, of a high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; about 31% by weight to about 45% by weight, based on total weight of the composition, of a solvent; about 2% by weight to about 10% by weight, based on total weight of the composition, of a rheology modifier; and a cellulose acetate butyrate. |
地址 |
Cupertino CA US |